I did my undergraduate study in my home country (Indonesia) before pursuing my MSc in another country (China). During my time abroad, my interest in nutrition and cancer started to grow and realised how I loved spending countless hours working in the lab. I am currently a PhD student here at Leeds with a research project focus on post-transcriptional and post-translational regulation of Liver X Receptors (LXRs) activity in breast cancer (BCa).
In the UK, BCa is the most common cancer diagnosed in women. BCa incidence rate continues to rise each year and about one in eight UK women will develop BCa. Approximately 70-80% of BCa patients, in particular patients with advanced BCa, most likely have developed resistance to chemotherapy treatment. Factors that contribute to BCa chemo-resistance are heterogeneous and efforts to seek novel targets for chemo-resistant BCa is crucial. There is a strong correlation between cholesterol accumulation and both BCa risk and poor prognosis. Elevated low-density lipoprotein-cholesterol (LDL-C) in BCa patient’s tumours is reported as a modifier of cancer cell aggressiveness in advanced BCa patients. LXRs, one of Nuclear Receptor (NR) family members, are believed to have a prominent role in mediating this link. LXRs act as cholesterol sensors and respond to a variety of endogenous and dietary ligands which involve in cholesterol metabolism. The LXR controlled transcriptome is thought to be differentially regulated by an array of factors, including multiple oxysterol ligands, alternative splicing and promoter usage, and post-translational modifications (PTMs). The specific hypotheses and aims of my project are to understand the underlying mechanisms of how LXR ligands, transcript variants, and PTMs combine to influence and drive BCa chemotherapy resistance is of importance for the future development of potent therapeutic agents.
- BSc Nutrition and Food Technology, Widya Mandala University
- MSc Nutrition and Food Safety, China Agricultural University