Zhihua (Maggie) Wu

Profile

I studied Food Science and Engineering (2020) and then obtained a master's degree in Biology and Medicine at the Ocean University of China (2023). Currently, I have a PhD researcher position at the School of Food Science and Nutrition at the University of Leeds (2023-present). 

With a background in food nutrition and immunology, I am passionate about bridging the gap between nutrition and molecular biology, transferring scientific discoveries into practical applications.

My current project aims to uncover the immunoregulatory effects of gut microbiota-derived metabolites (SCFAs) on T-cell functionality in Long-Covid. By integrating multi-disciplinary approaches (cell culture, flow cytometry, bioinformatics, etc.), I aim to bring up advanced nutrition interventions that address complex health challenges and contribute to the future of preventative and functional medicine.

Beyond academia, I’m passionately dedicated to science communication and have fostered a vibrant community on social media. I share health and nutrition research with engaging, evidence-based insights. By fostering a deeper public understanding of health, I have helped thousands make informed lifestyle choices to improve their well-being.

Research interests

Influence of Long-COVID specific gut microbiota-derived metabolites on the functionality of CD4 and CD8 T-cells (2023-present)

The project focuses on identifying specific changes in metabolites derived from gut microbiota in Long-Covid patients. My aim is to discover the gut-mediated regulatory effects on the immune system by developing an ex vivo T-cell functionality assay model. This study aims to suggest targetable pathways that could guide the development of future nutrition intervention strategies for improving patient outcomes in Long-Covid.

Immunostimulatory and immunoadjuvant capacities of soluble Rhamnan-type Ulva oligosaccharides (2020-2023)

This project delves into the immunomodulatory potential of Ulva oligosaccharides in both innate and adaptive immune systems. Through a combination of in vitro and in vivo experiments, as well as transcriptome sequencing analysis, I uncovered systemic pro-inflammatory responses and elucidated the molecular pathways involved in immune activation.