Dr James Smith

Dr James Smith

Profile

James joined the Chemistry & Biochemistry Section in the School in September 2016 as a University Lecturer in Biochemistry in Metabolic & Biophysical Modelling,.

During his postdoctoral research career, James held posts at the University of Cambridge, at the University of Elrangen Nuremberg, then as a Volkswagen Foundation Research Fellow at Jacobs University, Germany. After  a  lecturing post at Birbeck College London and UCL, James was appointment as an MRC Senior Investigator Scientist at MRC Human Nutrition Research, Elsie Widdowson Laboratory in Cambridge and was  a long-standing visiting lecturer at the Cambridge Computational Biology Institute, University of Cambridge.

Responsibilities

  • FS&N PGT Admissions
  • FS&N Academic Lead for Inclusive Pedagogies

Research interests

Collaborators

  • Iosifina SampsonRichard Bayliss and Valerie Speirs (University of Aberdeen) – Structural & systems biology of cancer.
  • Nick Parker & Andrew Baggaley (Newcastle University) and DEFRA, HMGov UK – Mathematical biology of environmental epidemic spread.
  • Chi-Ying Huang (National Yang Ming University, Taiwan) – Network biology in target prediction.
  • Garstka Malgorzata Anna (Xi'an Jiaotong University, Shaanxi, PR China) – Diagnostic biomarker discovery in early GDM
  • Ahmed M. Ibrahim (Mansoura, Dakahlia, Egypt) – Potential adjustment of gut microbe populations with a pro-phylactic nutritional strategy for metabolic syndrome
  • Babiker Badri (Ahfad University for Women, Omdurman, Sudan) – Natural product inspired re-design of anti-leishmanicidal agents
  • Nadia Hamdy (Ain Shams University, Cairo, Egypt) – Natural product inspired docking of anti-virals
  • Micheal J Wise (University of Western Australia) – Computational  and mathematical biology. 
  • Albert Koulman (Institute of Metabolic Sciences, University of Cambridge) – Computational biology.
  • Wuge Briscoe (University of Bristol) – Physical chemisry of membrane-ligand interactions

Recent Funding

  • Co-I Wellcome Trust (London)-funded University of Leeds Institutional Strategic Support Fund Discipline Hopping Fellowship for Iosifina Sampson 2020-2021 with Lucy Stead & Richard Bayliss and Mariko Okada (Osaka University).
  • EPSRC (UKRI, Swindon) 2283981 2019 – Modelling the structure and crystallisation of kidney stones
  • Wellcome Trust (London) UNS89407 2019 – Machine Learning Exploration of Circulating Biochemical Biomarkers for Gestational Diabetes 
  • British Council (Newton Funds), FAPESP (Brazilian Research agency) and ANII (Uruguayan Research Agency) – Exploring the potential of biological soft matter in AgriFood challenges 2018.
  • Co-I BBSRC DRINC (UKRI, Swindon)  BB/M027252/1 2015-2016 and BB/M027252/2 2016-2019 with Albert Koulman, (University of Cambridge)  – Validation of biomarkers of metabolic efficacy in infant nutrition

Current and Previous PhD Students

Alumni

Professional Activities

  • NIHR Grant Peer reviewer.
  • European Commission H2020 Registered Expert Evaluator.
  • Peer Reviewer for Computational & Mathematical Methods in Medicine, PLOS ONE, Journal of Theoretical Biology.

Local Recognition in Student Education

  • Shortllisted for The Academic Personal Tutor/ Supervisor Award and The Inspirational Teaching/Supervisor Award, Faculty of Environment Partnership Awards 2022
  • Shortlisted for The Academic Personal Tutor/ Supervisor Award,  Faculty of Environment Partnership Awards 2021.
  • Winner of The Academic Personal Tutor Award and shortlisted for The Supervisor Award, Faculty of Environment Partnership Awards 2020.
  • Shortlisted for The Inspirational Teaching Award, Faculty of Mathematics and Physical Sciences Partnership Awards 2018.
  • Shortlisted for The Supervisor Award, Faculty of Mathematics and Physical Sciences Partnership Awards 2017.
<h4>Research projects</h4> <p>Any research projects I'm currently working on will be listed below. Our list of all <a href="https://environment.leeds.ac.uk/dir/research-projects">research projects</a> allows you to view and search the full list of projects in the faculty.</p>

Qualifications

  • PhD Computer-aided Drug Design (Cantab)
  • BSc (Hons) Biological Sciences (Leicester)

Professional memberships

  • The Biochemical Society (London)
  • The British Pharmacological Society (London)
  • British Biophysical Society
  • The Nutrition Society (London)
  • Society for Mathematical Biology
  • Society for Natural Sciences

Student education

  • 2016 -  Course module lead for FOOD2032 & FOOD5242M covering nutritional chemistry, and functional biochemistry and molecular.biology.
  • 2016-2019 – Contributor for network and systems modelling for FOOD3130 food research: recent revelations and disputes.
  • 2019 -  Contributor for radical reaction mechanisms and fatty acid oxdation for FOOD5196M Impacts of Processing on Nutritional Quality.

Undergraduate and Masters Research Projects

I welcome motivated chemistry-focussed students wanting to explore bioinformatics and  the use of biomarkers in molecular epidemiology. I welcome Natural Sciences students motivated by multi-disciplinary projects including medicinal or biological chemistry, computational molecular biochemistry, or metabolic state  prediction in health and disease. I am also keen to host students with experience in computing and mathematics, especially formal methods for mathematical biology, biostatistics and interests in machine learning.

Every year, I host Summer vacation internships or  have collaborators interested in sharing students. Enquire early in the New Year if you are interested in joining my research group for a scholarship-funded project during the Summer. There are a number of organisations and societies listed here and here that offer funding and scholarships. 

Current and former research students

  • G  Sergalyte (2021-22) with Helen Chappell and  Riannnon Morris – DFT modelling of kidney microtubular urinary metabolite fragments with calcium oxalate.
  • T Ensor (2021-22) Bayesian cluster analysis of psychometric indicies to indicate mis-reporting in cohorts returning self-reported dietary assessments of their own energy intake.
  • H Panesar, S Yuan & Y Wang (2021) Network graphical models of modes of action of natural products for long COVID syndrome.
  • Y Jiang (2021) Functional analysis for coninuous glucose measurement time series from Type 1 diabetics.
  • Y Zhang (2021) Data analysis of breast milk fatty acid profile data under JASP.
  • A  Blick (2020-21) Analysis of individual dietary patterns and food intake and the misreporting when carrying out self-reported dietary assessments.
  • J Wills (2020-21) Analysis of historical trends of child-stunting and crop yield in Kenya.
  • I Blicknall & P Chalmers (2020-21) Analysis of de novo lipogenesis-associated TAG lipid  abundances between organs.
  • X Shen (2020) Polysaccharide organisation of marine biofilms, understanding the physicochemical constraints for the design of repellent surfaces for culinary use.
  • S Wu (2020) Interactions of drugs on cysteine-rich kidney stones.
  • P Zhang (2020) Assessing HbA1c measurements by Statistical modelling and clustering of blood pressure measurements.
  • M Li (2020) Discussing uncertainties in OGTT and CGM in the third trimester of pregnancy.
  • K Zhang (2020) with Nienyun Sharon Hsu and Yaowei Xun - Binding sites of oncogenic fusion proteins of non-small cell lung cancer.
  • T Liu & CW Chan (2019-20) Statistical modelling and clustering of blood pressure measurements.
  • O Taylor (2019-20) Re-assessment of unsupervised clustering of retrospective early gestational diabetes and OGTT clinical data.
  • E Wong (2019-20) Computer-aided drug design of peptide inhibitor binding for targets in basal-like breast cancer.
  • Y Jiang (2019-20) Computational Systems Biochemistry – Cyclic and feed-forward motif behaviour from flux patterns of anaplerotic metabolic reactions in E.coli.
  • O Taylor (2019) Wellcome Trust-funded Summer Studentship: An unsupervised multivariate analysis of early gestational diabetes clinical biomarkers.
  • Y Xun (2019) with Nienyun Sharon Hsu –  Molecular docking of SHC domains to short linear motifs from intrinsically disordered regions in proteins related to intracellular signalling. 
  • J Shu (2019) with Yuwei Li – Microbial and metabolic modelling of repeated Stag Hunt competition in cyclic Rock-Paper-Scissor interactions.
  • A Shen (2019) Systematic review of coagulation biomarkers on early gestational diabetes. 
  • T He (2019) Systematic review of the hepatic and trace element biomarkers on early gestational diabetes.
  • Y Zhang (2019) Systematic review of the thyroid and anaemia biomarkers on early gestational diabetes.
  • H Tong (2018-9) with Helen Chappell – Modelling interactions of aflatoxins and their metabolites with calcium phosphate,
  • G Gornall (2018-9) with Helen Chappell – Water activity and hydration shells of polyphenols.
  • S Holmes (2018-9) Rock-paper-scissor dynamics – Development of a cellular automaton model for interacting bacterial colonies.
  • L Potts (2018-9)  Identifying metabolic biomarker correlations in clinical data from early gestational diabetes.
  • K Daly (2018) Erasmus+ Project Student from DIT Dublin, Ireland: Quantitative methods for exploring metabolomics:
    i) Biostatistical methods for anthropometry landscape modelling according to dominant phospholipids in circulating lymphocytes. 
    ii) Unsupervised machine learning pattern recognition to characterise physiological biomarkers indicative of gestational diabetes in the first trimester. 
  • L Yeo (2018)  Phase I metabolism prediction of xenobiotics – A comparison of  mechanistic biotransformations by CYP2D6 and CYP2C9  predicted using SPORCalc.
  • Y Li (2018) Identification of functional motifs from GAB1 intrinsically disordered regions and an assessment of their stabilising interactions with SHC binding domains.
  • W Zhou (2018) Characterising PPI binding motifs in intrinsically disordered regions used by KIT protein signalling, for peptidomimetic drug target discovery in signalling protein aggregates in breast cancer. 
  • Z Ma (2017) Molecular recognition of isosterol and triterpenoid-based ligand-binding constraints to inform structure-based drug design.
  • D Wu (2017) Identification of potential drug targets from hub-associated motifs from transcription factor networks, found in basal (triple-negative) breast cancer patients. 
  • H Tong (2017) University of Leeds and EPSRC-funded Summer Studentship: Canonical correlation analysis  & combinatoric composition analysis of acyl abundance in phospholipids and neutral acylglycerol, derived from large scale lipidomics. 
  • M  Liu (2017) Discrimination of Her2 and Luminal – A breast cancer patients revealed by hierarchical clustering of nuclear receptor expression patterns.
  • W Pan (2017) Explicit solvent molecular modelling – Hydrogen-bonding networks determined from conformational sampling of MD-generated conformation ensembles (with AMBER) followed by geometry optimisation with DFT (with CASTEP). 
  • A  Ackroyd (2016-7) with Alan Mackie – Time-dependent correlation clustering analysis to reveal coherence between self-reported satiety  with physiological  data collected from lateral MRI imaging and circulating blood biomarkers linked to gastric emptying.
  • A  Bawden (2016-7) 2D machine learning stratification of fat lipid biomarkers, useful for molecular epidemiology and fish-oil intervention studies.
  • M Harland (2016-7) with David Hauton – Regressing cardiac QT and RR interval signals to both logarithmic and parabolic models to determine  the accuracy of QTc interval changes during cardiovascular exercise and nitrate supplementation.

 

Research groups and institutes

  • Food Chemistry and Biochemistry
  • Obesity, Cancer and Metabolic Disease

Current postgraduate researchers

<h4>Postgraduate research opportunities</h4> <p>We welcome enquiries from motivated and qualified applicants from all around the world who are interested in PhD study. Our <a href="https://phd.leeds.ac.uk">research opportunities</a> allow you to search for projects and scholarships.</p>