- Position: Analytical Biochemistry
- Areas of expertise: Biology, Analytical Biochemistry, Microbiology, Metabolic Engineering, Biomedicine, Health Sciences
- Email: C.M.Ferreira@leeds.ac.uk
- Phone: +44(0)113 343 1970
- Location: 7.86 E.C Stoner
My interest for Science start at early ages when I received a Microscope for my 7th Birthday. I started to inspect from little animals I found on the garden, plants, food and always knew I wanted to be a Scientist. In 1993 for my University degree I choose Food Engineering in Portuguese Catholic University as the 5th year of this course consisted on an International placement in a Research Institution. I went to The Netherlands to NIZO- Dairy research Institute working with selection and isolation of Bifidobacterium for dairy fermented products, namely yogurts, where I stayed as researcher until 1996. From 1997 till I started my PhD in 2001, I went to Microbiology Department of Coimbra University, Portugal, where I research Thermophilic bacteria stress response. I got my PhD in Sciences-Molecular Biology in 2005, this was done in Denmark in the Carlsberg Research Centre studying stress response, namely osmotic stress response of the yeast Saccharomyces cerevisiae. Next, I did a Posdoc in Minho University, Portugal, continuing the studies of the PhD and exploring new fields, metabolic engineering yeasts to produce bioethanol, biodiesel, and lipids from waste products, exploring the yeast wall composition and integrity aiming to understand the mechanisms underlying antifungal resistance, biofilm formation, the switch from commensal to virulent state of pathogenic yeasts and the immune response. From 2009-2015 I got a position of Associated professor/researcher in the Biology department of Minho University which included 40% of lecturing at undergraduate and postgraduate levels. I started a new research line on humanized yeasts. We generate humanized-yeast/transgenic-yeasts expressing human genes involved on the onset and progression of cancer, extracellular matrix formation and cancer signalling. In 2015 I moved to the Faculty of Biological Sciences of the University of Leeds, as a senior research fellow using the nematode C. elegans to study Ageing and Neurobiology, namely on the effects of Ca2+ dyshomeostasis in muscle disorders and Alzheimer's disease. I came to the School of Food Science and Nutrition in the end of 2018 as a Teacher in Analytical Biochemistry, and I am particular interested in exploring how food choices may provide cognitive benefits over age, influence risk of on-set and progression of dementia, memory loss, Alzheimer disease. I am also keen in exploring Food of future topics- sustainable nutrient sources- role of non-pathogenic worms and/or microorganisms.
My research involved diverse model organisms microbes (bacteria, yeasts and virus) and animals (C. elegans) and multidisciplinary approaches connecting cellular and molecular biology, genetics, microbiology, biochemistry, genomics, proteomics, lipidomics, glycomics and mass spectrometry. It focused in relevant real-world problems, aiming at elucidate: a) biomedical questions, namely microbial pathogenesis, mechanisms of antibiotic and antifungal resistance, endolysins as alternatives to antibiotics, cellular, molecular aspects and signalling pathways underlying cancer onset and progression, glycobiology, glycopharmacology and microbial bioactive compounds, and in recent years Ageing and Neurobiology, namely on the study of Ca2+ dyshomeostasis in muscle disorders and Alzheimer's disease and how food choices may influence the later; and b) biotechnological improvements, using microbes for improved bioactive dairy fermented products, innovation for the backer yeast and fuel industries.<h4>Research projects</h4> <p>Any research projects I'm currently working on will be listed below. Our list of all <a href="https://environment.leeds.ac.uk/dir/research-projects">research projects</a> allows you to view and search the full list of projects in the faculty.</p> <h4>Postgraduate research opportunities</h4> <p>We welcome enquiries from motivated and qualified applicants from all around the world who are interested in PhD study. Our <a href="https://phd.leeds.ac.uk">research opportunities</a> allow you to search for projects and scholarships.</p>